2024 |
#72 Myosin VI drives arrestin-independent internalization and signaling of GPCRs
Nat Commun. 2024 Dec 6;15(1):10636. doi: 10.1038/s41467-024-55053-9. Full Text: Link |
#71Cellular lipids regulate the conformational ensembles of the disordered intracellular loop 3 in β2-adrenergic receptor
iScience 2024 May 23;27(6):110086. doi: 10.1016/j.isci.2024.110086 Full Text: Link |
#70Tail length and E525K dilated cardiomyopathy mutant alter human β-cardiac myosin super-relaxed state
J Gen Physiol 2024 Jun 3;156(6):e202313522. doi: 10.1085/jgp.202313522 Full Text: Link |
2023 |
#79Autoregulation of GPCR signalling through the third intracellular loop
Nature 2023 Mar;615(7953):734-741. doi: 10.1038/s41586-023-05789-z Full Text: Link PDF |
2022 |
![Molecular models of the M2β 15HPZ.GFP construct in open and closed (interacting-heads motif [IHM]) states](/sites/proteinacrobaticslab.umn.edu/files/styles/folwell_half/public/2024-11/elife-77415-fig1.jpg?itok=iudLykPM)
#68Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting-heads motif and super-relaxed state of myosin
Elife 2022 Nov 24:11:e77415. doi: 10.7554/eLife.77415 Full Text: Link PDF |
#67Kinesin-3 motors are fine-tuned at the molecular level to endow distinct mechanical outputs
BMC Biol 2022 Aug 10;20(1):177. doi: 10.1186/s12915-022-01370-8 Full Text: Link PDF |
#66Effect of Ligands and Transducers on the Neurotensin Receptor 1 Conformational Ensemble
J Am Chem Soc. 2022 Jun 15;144(23):10241-10250. doi: 10.1021/jacs.2c00828. Full Text: Link PDF |
#65Nanosurfer assay dissects β-cardiac myosin and cardiac myosin-binding protein C interactions
Biophys J. 2022 Jun 21;121(12):2449-2460. doi: 10.1016/j.bpj.2022.05.013. Full Text: Link PDF |
#64Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling
Nat Commun 2022, Mar 8;13(1):1202. doi: 10.1038/s41467-022-28789-5 Full Text: Link PDF |
#63Multimodal regulation of myosin VI ensemble transport by cargo adaptor protein GIPCAshim Rai, Rachit Shrivastava, Duha Vang, Michael Ritt, Fredrik Sadler, Shreyas Bhaban, Murti Salapaka, Sivaraj Sivaramakrishnan J Biol Chem 2022, Mar; doi:10.1016/j.jbc.2022.101688 Full Text: Link PDF
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2021 |
#62β2-adrenoceptor ligand efficacy is tuned by a two-stage interaction with the Gαs C-terminusKeehun Kim, Shayla Paulekas, Fredrik Sadler, Tejas Gupte, Michael Ritt, Matthew Dysthe, Nagarajan Vaidehi, Sivaraj Sivaramakrishnan PNAS March 2021; 118(11)
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#61KIF13A motors are regulated by Rab22A to function as weak dimers inside the cellNishaben M. Patel, Meenakshi Sundaram Aravintha Siva, Ruchi Kumari, Dipeshwari J. Shewale, Ashim Rai, Michael Ritt, Prerna Sharma, Subba Rao Gangi Setty, Sivaraj Sivaramakrishnan, and Virupakshi Soppina Sci Advances 2021; Feb 3;7(6):eabd2054.doi: 10.1126/sciadv.abd2054 |
#60Kinase inhibitors allosterically disrupt a regulatory interaction to enhance PKCα membrane translocationLisa G. Lippert*, Ning Ma*, Michael Ritt*, Abhinandan Jain, Nagarajan Vaidehi, Sivaraj Sivaramakrishnan J Biol Chem 2021; Jan 25;doi: 10.1016/j.jbc.2021.100339 |
#59ER/K-link-Leveraging a native protein linker to probe dynamic cellular interactions.Tejas Gupte, Michael Ritt, Sivaraj Sivaramakrishnan Methods in Enzymology 2021;647:173-208. Full text: Link PDF available on request |
2020 |
#58Dynamic multimerization of Dab2-Myosin VI complexes regulates cargo processivity while minimizing cortical actin reorganizationAshim Rai*, Duha Vang*, Michael Ritt, Sivaraj Sivaramakrishnan J Biol Chem 2020;Dec 28;jbc.RA120.012703. (Selected as Editor's Pick) |
#57Allosteric modulation of adenosine A1 and cannabinoid 1 receptor signaling by G‐peptidesAnja M. Touma, Rabia U. Malik, Tejas Gupte, Sivaraj Sivaramakrishnan Pharm Res Persp 2020 Dec;8(6):e00673. |
#56Optical Mapping of cAMP Signaling at the Nanometer ScaleAndreas Bock, Paolo Annibale, Charlotte Konrad, Annette Hannawacker, Selma E. Anton, Isabella Maiellaro, Ulrike Zabel, Sivaraj Sivaramakrishnan, Martin Falcke, and Martin J. Lohse Cell 2020 Aug 25; 10, 4836 |
2019 |
#55Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signalingTejas Gupte, Michael Ritt, Matthew Dysthe, Rabia Malik, and Sivaraj Sivaramakrishnan Nature Communications 2019 Oct 23; 10, 4836 |
#54Stiffness of Cargo–Motor Linkage Tunes Myosin VI Motility and Response to LoadRachit Shrivastava, Ashim Rai, Murti Salapaka, and Sivaraj Sivaramakrishnan Biochemistry 2019 Sept 11; 58, 47, 4721–4725 (Featured cover article) |
#53Conformational plasticity of the intracellular cavity of GPCR-G-protein complexes leads to G-protein promiscuity and selectivity.Manbir Sandhu, Anja M. Touma, Matthew Dysthe, Fredrik Sadler, Sivaraj Sivaramakrishnan, and Nagarajan Vaidehi PNAS 2019 May 28; epub ahead of print |
2018 |
#52Bitopic Inhibition of ATP and Substrate Binding in Ser/Thr Kinases through a Conserved Allosteric MechanismNing Ma, Lisa G. Lippert, Titu Devamani, Benjamin Levy, Sangbae Lee, Manbir Sandhu, Nagarajan Vaidehi, and Sivaraj Sivaramakrishnan Biochemistry 2018 Oct 18; 57(45): 6387–90
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#51Engineering Synthetic Myosin Filaments Using DNA NanotubesSommese R, Sivaramakrishnan S Molecular Motors: Methods in Molecular Biology 2018 Jul 4; 1805: 93-101 Full Text: Link
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#50Engaging myosin VI tunes motility, morphology, and identity in endocytosisRitt M, Sivaramakrishnan S Traffic. 2018 Jun 4; 19:710–722 |
2017 |
#49Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactomeSkinner JJ, Wang S, Lee J, Ong C, Sommese R, Sivaramakrishnan S, Koelmel W, Hirschbeck M, Schindelin H, Kisker C, Lorenz K, Sosnick TR, Rosner MR. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13453-13458 |
#48Distinct structural mechanisms determine substrate affinity and kinase activity of Protein Kinase Cα |
#47ER/K Linked GPCR-G protein fusions systematically modulate second messenger response in cells |
#46Actin turnover maintains actin filament homeostasis during cytokinetic ring contraction |
#45The DRY motif and the four corners of the cubic ternary complex model |
#44Priming GPCR signaling through the synergistic effect of two G proteins |
#43The GCaMP-R Family of Genetically Encoded Ratiometric Calcium Indicators |
#42The role of regulatory domains in maintaining auto-inhibition in the multi-domain kinase PKCα |
2016 |
#41Calcium Stimulates Self-Assembly of Protein Kinase C α In Vitro |
#40G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay |
#39Patterning protein complexes on DNA nanostructures using a GFP nanobody |
#38Engineering Circular Gliding of Actin Filaments Along Myosin-Patterened DNA Nanotube Rings To Study Long-Term Actin-Myosin Behaviors |
#37Substrate Affinity Differentially Influences Protein Kinase C Regulation and Inhibitor Potency |
#36Structural elements in the Gαs and Gαq C-termini that mediate selective GPCR signaling. |
2015 |
Dynamic coupling and allosteric networks in the alpha subunit of heterotrimeric G proteins. |
#33Using Protein Dimers to Maximize the Protein Hybridization Efficiency with Multisite DNA Origami Scaffolds. |
#32Mechanical coordination in motor ensembles revealed using engineered artificial myosin filaments. |
#31Cellular chirality arising from the self-organization of the actin cytoskeleton. |
#30The C2 domain and altered ATP-binding loop phosphorylation at Ser359 mediate the redox-dependent increase in Protein Kinase Cδ activity. |
#29Tuning myosin-driven sorting on cellular actin networks. |
2014 |
#28A method for multiprotein assembly in cells reveals independent action of kinesins in complex. |
#27Optofluidic lasers with a single molecular layer of gain. |
#26Natural Killer Cells Eradicate Galectin-1-Deficient Glioma in the Absence of Adaptive Immunity. |
#25Harnessing the unique structural properties of isolated α-helices. |
#24Conserved modular domains team up to atch-open Active protein kinase Cα. |
#23Myosin lever arm directs collective motion on cellular actin network. |
2013 |
#22Analyses of conformational states of the transporter associated with antigen processing (TAP) in a native cellular membrane environment. |
#21Agonist Activated PKCβII Translocation and Modulation of Cardiac Myocyte Contractile Function. |
#20Detection of G Protein-selective G Protein-coupled Receptor (GPCR) Conformations in Live Cells. |
#19Highly sensitive fluorescent protein FRET detection using optofluidic lasers. |
#18Visualizing and manipulating focal adhesion kinase regulation in live cells.Ritt M, Guan JL, Sivaramakrishnan S. |
2012 |
#17Cell-intrinsic functional effects of the α-cardiac myosin Arg-403-Gln mutation in familial hypertrophic cardiomyopathy. |
#16Dual-beam optical tweezers.Sivaramakrishnan S, Sung J, Dunn A, Spudich JA. Encyclopedia of Biophysics, Ed. Gordon Roberts, Springer. Full Text: PDF |
2011 |
#15Systematic control of protein interaction using a modular ER/K α-helix linker.Sivaramakrishnan S, Spudich JA. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20467-72. |
#14Principles of unconventional myosin function and targeting. |
2010 and earlier |
#13Helicity of short E-R/K peptides. |
#12Single-molecule dual-beam optical trap analysis of protein structure and function. |
#11Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis. |
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#9Coupled myosin VI motors facilitate unidirectional movement on an F-actin network. |
#8Insights into human beta-cardiac myosin function from single molecule and single cell studies. |
#7Shear stress induced reorganization of the keratin intermediate filament network requires PKC zeta. |
#6Dynamic charge interactions create surprising rigidity in the ER/K alpha-helical protein motif. |
#5Long single alpha-helical tail domains bridge the gap between structure and function of myosin VI. |
#4Micromechanical properties of keratin intermediate filament networks.Sivaramakrishnan S, DeGuilio JV, Lorand L, Goldman RD, Ridge KM. Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):889-94 |
#3Computational and Experimental Study of Turbulent Flow in a 0.4-Scale Water Model of a Continuous Steel Caster. |
#2Transient Fluid Flow in the Continuous Steel-slab Casting Mold.Thomas BG, Yuan Q, Sivaramakrishnan S, Vanka SP. Journal of Metals - Electronic Edition, 2002, 54(1). Full Text: Link |
#1Comparison of four methods to evaluate fluid velocities in a continuous slab casting mold.B.G. Thomas, Q. Yuan, S. Sivaramakrishnan, T. Shi, S.P. Vanka and M.B. Assar, ISIJ Int., 2001, 41(10), 1262-1271. Full Text: PDF |
